• Hana KALOVÁ
  • Brigita JANEČKOVÁ
  • Petr PETR
  • Miroslav VERNER
  • Jarmila BOČKOVÁ
  • Alena SEBOROVÁ
  • Jan REBAN


The presented study is focused on contemporary knowledge and concepts concerning health benefits of the blueberries on the human health. They compare their effects on the brain and nervous system and on the mnestic, cognitive and sensory functions (with a special regard to the sight), locomotor functions (with a special regard to the balance and gait), antisclerotic, cardioprotective and angioprotective effects, potential anti-cancer effects and general protective effects (with a special regard to the ageing process). Contents of micronutrients present in the blueberries for the health are detailed. Differences in the importance of micronutrients and further effective substance are explained based on the RDA (Recommended Daily Allowance) value. Basic and well attainable literature is quoted, which offers detailed outlines of effective phytochemical substances in the bilberry and of the botanic classification and variations.

Key words: European blueberries, Vaccinium myrtillus, importance for human health, prevention, mental functions, physical functions, ageing


Agarwal, K. CH. (2011). Mechanism-based biochemicial standardisation of resveratrol products and their uses thereof. US Patent Application, US 2011/002 1640 A1, Appl. No.: 12/004 633, Filed: Jul 26, 2010, US Publication Classification 514/733 435/18.

Balík, J., Kyseláková, M., Vrchotová, N., Tříska, J., Kumšta, M., Veverka, J., Híc, P., Totušek, J., Lefnerová, D. (2008). Relations between Polyphenols Content and Antioxidant Activity in Vine Grapes and Leaves. Czech J. Food Sci. 26: S25–S32.

Basu, A., Rhone, M., Lyons, T. J. (2010). Berries: emerging impact on cardiovascular health. Nutr. Rev. 68 (3): 168–177.

Bauer, J. (2011). Foods That Boost Your Memory. [online] [cit. 2012-03-11]. Available on:

Beattie, J., Crozier, A., Duthie, G. G. (2005). Potential Health Benefits of Berries. Current Nutrition and Food Science. 1: 71–86.

Delmas, D., Lancon, A., Colin, D., Jannin, B., Tatruffe, N. (2006). Resveratrol as a Chemopreventive Agent: A Promissing Molecule for Fighting Cancer. Current Drug Targets. 7(4)4: 423–442.

Chen, J-R., Lazarenko, O. P., Wu, X., Kang, J., Blackburn, M. L., Shankar, K. et al. (2010). Dietary – induced serum phenolic acids promote bone growth via p38 MARK/ beta catenin canonical Wnt signalling. Journal of Bone and Mineral Research. 25(11): 2939–2411.

Functional Foods Research in ARS. (2010). [online] USDA Agricultural Research Service. [cit. 2012-02- 21]. Available on: http://www.ars.usda.


Gheldof, N., Engeseth, N. J. (2002). Antioxidant Capacity of Honeys from variol Floral Sources Based on the Determination of Oxygen Radfical Absorbance Capacity and Inhibiton of in Vitro Lipoprotein Oxidation in Human Serum Samples. Journal of Agricultural and Food Chemistry. 50(10): 3040–3055.

Giongo, L. A. R. A., Ieri, F., Vrhovsek, U., Grisenti, M., Mattivi, F., & Eccher, M. (2004, May). Characterization of Vaccinium cultivars: horticultural and antioxidant profile. In VIII International Symposium on Vaccinium Culture 715 (pp. 147-152).

Greenwell I (2000). Antioxidant Power. Blueberries and bilberries slow ageing and protect vision. [online] [cit. 2012-02-01]. Life Extension Magazine, March 2000, Cover Story. Avialable on:


Han, Y-S., Bastianetto, S., Dumont, Y., Quirion, R. (2006). Specific Plasma Membrane Binding Sites for Polyphenols, Including Resveratrol, in the Rat Brain. The Journal of Pharmacology and Experimental Therapeutics. 318: 238–245.

Herbs, A-E. (2012). [online] U.S. Army HOOAH 4 HEALTH. [cit. 2012-03-12]. Available on: http://

Kalt, W. (2010). Blueberries Leave Indelible Mark on Good Health. [online] [cit. 2012-02-01]. Agriculture and Agri-Food Canada. Available on: http://


Kaplan, K. (2011). Historic Collection at NAL (National Agricultural Library) Gives Insight into Blueberry’s Domestication. [online] [cit. 2012-02- 12]. Agricultural Research Magazine. Available on: http://www.

Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., Blomhoff, R. (2010). Bilberry juice modulates plasma concentration of NF-B inflammatory markers in subjects at increased risk of CVD. European Journal of Nutrition. 49(6): 345–355.

Klán, J., Topinková, E. (2003). Pády a jejich rizikové faktory ve stáří. Česká geriatrická revue. 2: 38–43.

Lotito, S. B., Frei, B. (2006). Consumption of flavonoidrich fous and increased plasma antioxidant capacity in humans: Cause, consequence or epiphenomenon? Free Radical Biology and Medicine 41(12, 15): 1727–1746.

Lyons, M. M., Toma, R. B., Cho, S. Y., Lee, J., van Breemen, R. B. (2003). Resveratrol in raw and baked blueberries nad bilberries. J Agric Food Chem. 24: 51(20): 5867– 5870.

Petr, P, Kalová, H. (2006). Nutraceutika. Vybrané kapitoly z nutraceutické teorie a praxe. Studia VI. České Budějovice: VŠERS, s. 47.

Quideau, S., Defrieux, D., Douat-Casassus, C., Puysegu, L. (2011). Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis. Angewandte Chemie, International Edition. 50(3): 586–621.

Ronis, M., Badeaux, J., Seely, K., Rodgers, B., Wu, X., Prior, R., Bager, T. (2006). Feeding of Casein Diets Supplemented with Blueberry or Grape Powder During Development Alters Hepatic Phase I and II Metabolism in Sprague Dawley Rats. Journal of Federation of American Societies of Experimental Biology, FASEB Journal. 20(4): A1014.

Satanina, V. (2011). Optimization of Hydrothermodynamic Technology for Blueberry Food Processing. [online] [cit. 2012-03-12]. Dalspace Repository. Dalhousie University, Canada. Available on: http://dalsp

Schmidt, B. M., Erdmann, J. W., Jr., Lila, M. A. (2005). Effects of Food Processing on Blueberry Antiproliferation and Antioxidant Activity. Journal of Food Science. 70(6): 389–394.

Sweeney, M. I., Kalt, W., MacKinnon, S. L., Ashby, J., Gottschall-Pass, K. T. (2002). Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia induced brain damage. Nutr Neurosci. 5(6): 427–431.

Tinetti, M. E. (2003). Preventing Falls in Elderly Persons. N Engl J Med. 348: 42–49.

Topinková, E. (2005). Geriatrie pro praxi. Praha: Galén, s. 270.

Wang, Y., Chang, C. F., Chou, J., Chen, H. L., Deng, X., Harvey, B. K.,

Cadet, J. L., Bickford, P. C. (2005). Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Exp. Neurol. 193 (1): 75–84.

Willis, L. M., Shukitt-Hale, B., Joseph, J. A. (2009). Recent advantages in berry supplementation and age-related cognitive decline. Current Opinion in Clinical Nutrition and Metabolic Care. 12(1): 91–94.

Wood, M. (2011). Blueberries and Your Health. Scientists Study Nutrition Secrets of Popular Fruit. [online] [cit. 2012-02-12]. Agricultural Research Magazine. U.S.A. Available on:

Xie, Ch., Kang, J., Chen, J-R., Nagarajan, S., Badger, T. M., Wu, X. (2011). Phenolic Acids Are in Vivo Atheroprotective Compounds Appearing in the Serum of Rats after Blueberry Consumption. J Agric Food Chem. 59 (18): 10381–10387.