Prevalence of frailty syndrome and its predictors in the population of people with intellectual disability compared to the general population: a systematic review

Authors

  • Diana Celebańska Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland
  • Eliza Gaweł Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland
  • Zuzana Kornatovská University of South Bohemia in České Budějovice
  • Barabara Rosołek Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland
  • Anna Zwierzchowska Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education in Katowice, Poland

DOI:

https://doi.org/10.58743/asv2022vol10no1.312

Keywords:

aging, elderly, older adults, frailty

Abstract

The aim of the systematic review was to evaluate the prevalence of the frailty syndrome (FS) and to identify its predictors in people with intellectual (ID) and developmental (DD) disabilities. It was assumed that in people with ID in adulthood period and early elderly period (20-60 years old) the ageing process (lower mobility in joints, frequent falls, the incidence of the coexist diseases and disability) occurs earlier and more frequent than in general population.  The methodology of this systematic review was planned according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search of electronic databases (PubMed, EBSCO, MEDLINE) was conducted to identify all studies on the incidence of the FS in people with intellectual disabilities from 2010 to 2022 based on the physical and functional status. In contrary to the general population, the assessment of the prevalence of FS among people with ID and DD was performed mostly with multivariant model. Age, gender, coexist diseases, mobility impairment in everyday life activities and Down syndrome were identified as the most frequent predictors of FS among the studied populations. In conclusion, the prevalence of FS among people with ID was diverse (9-27%) and included the following variables: coexisting diseases, coupled disability, intelligence quotient, everyday life activities, dwelling place. Moreover FS was found to occur significantly earlier (from 10 to 25 years) than in general population. Future studies should include the assessment of FS based on both phenotype and multivariant models.

References

Bagshaw, S. M., Stelfox, H. T., McDermid, R. C., Rolfson, D. B., Tsuyuki, R. T., Baig, N., Artiuch, B., Ibrahim, Q., Stollery, D. E., Rokosh, E., & Majumdar, S. R. (2014). Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 186(2), E95–E102. https://doi.org/10.1503/cmaj.130639

Brehmer, B., Weber, G. (2010). Frailty vs. Disability Distinctions in People With Intellectual Disabilities. Journal of Policy & Practice in Intellectual Disabilities, 7(1), 49-58.

Brehmer-Rinderer, B., Zeilinger, E. L., Radaljevic, A., & Weber, G. (2013). The Vienna Frailty Questionnaire For Persons with Intellectual Disabilities--Revised. Research in developmental disabilities, 34(6), 1958–1965. https://doi.org/10.1016/j.ridd.2013.03.004

Celebańska, D., & Gawlik, K. (2013). Level of physical activity in intellectually disabled adults. Physiotherapy Quarterly, 21(3), 27.

Chow, B. C., Choi, P., & Huang, W. (2018). Physical Activity and Physical Fitness of Adults with Intellectual Disabilities in Group Homes in Hong Kong. International journal of environmental research and public health, 15(7), 1370. https://doi.org/10.3390/ijerph15071370

Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013). Frailty in elderly people. Lancet (London, England), 381(9868), 752–762. https://doi.org/10.1016/S0140-6736(12)62167-9

Di Ciaula, A., & Portincasa, P. (2020). The environment as a determinant of successful aging or frailty. Mechanisms of ageing and development, 188, 111244. https://doi.org/10.1016/j.mad.2020.111244

Diaz, R., Hernandez-Vaquero, D., Alvarez, R., Moris, C., & Silva, J. (2015). Frailty Plays a Key Role after Cardiac Surgery. Heart, lung & circulation, 24(9), 940. https://doi.org/10.1016/j.hlc.2015.03.022

Ding, Y. Y., Kuha, J., & Murphy, M. (2017). Multidimensional predictors of physical frailty in older people: identifying how and for whom they exert their effects. Biogerontology, 18(2), 237–252. https://doi.org/10.1007/s10522-017-9677-9

Evenhuis H. M. (2014). Niet eerder oud, maar eerder ongezond: de kwetsbaarheid van mensen met verstandelijke beperkingen [Poor health at an earlier age: frailty in people with intellectual disabilities]. Nederlands tijdschrift voor geneeskunde, 158, A8016.

Evenhuis, H. M., Hermans, H., Hilgenkamp, T. I., Bastiaanse, L. P., & Echteld, M. A. (2012). Frailty and disability in older adults with intellectual disabilities: results from the healthy ageing and intellectual disability study. Journal of the American Geriatrics Society, 60(5), 934–938. https://doi.org/10.1111/j.1532-5415.2012.03925.x

Evenhuis, H., Schoufour, J., & Echteld, M. (2013). Frailty and intellectual disability: a different operationalization?. Developmental disabilities research reviews, 18(1), 17–21. https://doi.org/10.1002/ddrr.1124

Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., McBurnie, M. A., & Cardiovascular Health Study Collaborative Research Group (2001). Frailty in older adults: evidence for a phenotype. The journals of gerontology. Series A, Biological sciences and medical sciences, 56(3), M146–M156. https://doi.org/10.1093/gerona/56.3.m146

Gawlik, K., Zwierzchowska, A., & Celebańska, D. (2018). Impact of physical activity on obesity and lipid profile of adults with intellectual disability. Journal of applied research in intellectual disabilities : JARID, 31(2), 308–311. https://doi.org/10.1111/jar.12406

Gawlik, K., Zwierzchowska, A., Manowska, B., & Celebańska, D. (2016). Aerobic capacity of adults with intellectual disabilities. Annals of agricultural and environmental medicine : AAEM, 24(1), 117–120. https://doi.org/10.5604/12321966.1233999

Goldfarb, M., Sheppard, R., & Afilalo, J. (2015). Prognostic and Therapeutic Implications of Frailty in Older Adults with Heart Failure. Current cardiology reports, 17(11), 92. https://doi.org/10.1007/s11886-015-0651-3

Hsieh, K., Hilgenkamp, T., Murthy, S., Heller, T., & Rimmer, J. H. (2017). Low Levels of Physical Activity and Sedentary Behavior in Adults with Intellectual Disabilities. International journal of environmental research and public health, 14(12), 1503. https://doi.org/10.3390/ijerph14121503

Lee, C., Ouellette-Kuntz, H., Martin, L. (2019). Applying the HC-IDD Frailty Index to Developmental Services Agency Chart Data. Journal on Developmental Disabilities, 24(2), 43-50.

Lin, S. Y., & Tseng, H. C. (2022). Short-Term Changes of Frailty in Prematurely Aging Adults With Intellectual Disability. Intellectual and developmental disabilities, 60(1), 57–65. https://doi.org/10.1352/1934-9556-60.1.57

Ma, L. L., Wang, Y. Y., Yang, Z. H., Huang, D., Weng, H., & Zeng, X. T. (2020). Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better?. Military Medical Research, 7(1), 7. https://doi.org/10.1186/s40779-020-00238-8

Martin, L., McKenzie, K., & Ouellette-Kuntz, H. (2018). Once frail, always frail? Frailty transitions in home care users with intellectual and developmental disabilities. Geriatrics & gerontology international, 18(4), 547–553. https://doi.org/10.1111/ggi.13214

McKenzie, K., Ouellette-Kuntz, H., & Martin, L. (2015). Using an accumulation of deficits approach to measure frailty in a population of home care users with intellectual and developmental disabilities: an analytical descriptive study. BMC geriatrics, 15, 170. https://doi.org/10.1186/s12877-015-0170-5

Mendiratta, P., & Latif, R. (2021). Clinical Frailty Scale. In StatPearls. StatPearls Publishing.

Morley, J. E., Vellas, B., van Kan, G. A., Anker, S. D., Bauer, J. M., Bernabei, R., Cesari, M., Chumlea, W. C., Doehner, W., Evans, J., Fried, L. P., Guralnik, J. M., Katz, P. R., Malmstrom, T. K., McCarter, R. J., Gutierrez Robledo, L. M., Rockwood, K., von Haehling, S., Vandewoude, M. F., & Walston, J. (2013). Frailty consensus: a call to action. Journal of the American Medical Directors Association, 14(6), 392–397. https://doi.org/10.1016/j.jamda.2013.03.022

O'Connell, J., Henman, M. C., McMahon, N., Burke, É., McCallion, P., McCarron, M., & O'Dwyer, M. (2020). Medication burden and frailty in older adults with intellectual disability: An observational cross-sectional study. Pharmacoepidemiology and drug safety, 29(4), 482–492. https://doi.org/10.1002/pds.4987

Oresanya, L. B., Lyons, W. L., & Finlayson, E. (2014). Preoperative assessment of the older patient: a narrative review. JAMA, 311(20), 2110–2120. https://doi.org/10.1001/jama.2014.4573

Ouellette-Kuntz, H., Martin, L., & McKenzie, K. (2018). Rate of deficit accumulation in home care users with intellectual and developmental disabilities. Annals of epidemiology, 28(4), 220–224. https://doi.org/10.1016/j.annepidem.2018.01.010

Pilotto, A., Custodero, C., Maggi, S., Polidori, M. C., Veronese, N., & Ferrucci, L. (2020). A multidimensional approach to frailty in older people. Ageing research reviews, 60, 101047. https://doi.org/10.1016/j.arr.2020.101047

Rajabali, N., Rolfson, D., & Bagshaw, S. M. (2016). Assessment and Utility of Frailty Measures in Critical Illness, Cardiology, and Cardiac Surgery. The Canadian journal of cardiology, 32(9), 1157–1165. https://doi.org/10.1016/j.cjca.2016.05.011

Rockwood, K., & Mitnitski, A. (2007). Frailty in relation to the accumulation of deficits. The journals of gerontology. Series A, Biological sciences and medical sciences, 62(7), 722–727. https://doi.org/10.1093/gerona/62.7.722

Schoufour, J. D., Echteld, M. A., Bastiaanse, L. P., & Evenhuis, H. M. (2015a). The use of a frailty index to predict adverse health outcomes (falls, fractures, hospitalization, medication use, comorbid conditions) in people with intellectual disabilities. Research in developmental disabilities, 38, 39–47. https://doi.org/10.1016/j.ridd.2014.12.001

Schoufour, J. D., Echteld, M. A., Boonstra, A., Groothuismink, Z. M., & Evenhuis, H. M. (2016). Biochemical measures and frailty in people with intellectual disabilities. Age and ageing, 45(1), 142–148. https://doi.org/10.1093/ageing/afv152

Schoufour, J. D., Echteld, M. A., & Evenhuis, H. M. (2015b). Kwetsbaarheid bij ouderen met een verstandelijke beperking: operationalisering, risico en opsporing [Frailty in people with intellectual disabilities: operationalization, risks and detection]. Tijdschrift voor gerontologie en geriatrie, 46(2), 92–103. https://doi.org/10.1007/s12439-015-0126-4

Schoufour, J. D., Echteld, M. A., & Evenhuis, H. M. (2017). Comparing two frailty concepts among older people with intellectual disabilities. European journal of ageing, 14(1), 63–79. https://doi.org/10.1007/s10433-016-0388-x

Schoufour, J. D., Mitnitski, A., Rockwood, K., Evenhuis, H. M., & Echteld, M. A. (2013). Development of a frailty index for older people with intellectual disabilities: results from the HA-ID study. Research in developmental disabilities, 34(5), 1541–1555. https://doi.org/10.1016/j.ridd.2013.01.029

Schoufour, J. D., Mitnitski, A., Rockwood, K., Evenhuis, H. M., & Echteld, M. A. (2015c). Predicting 3-year survival in older people with intellectual disabilities using a Frailty Index. Journal of the American Geriatrics Society, 63(3), 531–536. https://doi.org/10.1111/jgs.13239

Schoufour, J. D., Mitnitski, A., Rockwood, K., Hilgenkamp, T. I., Evenhuis, H. M., & Echteld, M. A. (2014). Predicting disabilities in daily functioning in older people with intellectual disabilities using a frailty index. Research in developmental disabilities, 35(10), 2267–2277. https://doi.org/10.1016/j.ridd.2014.05.022

Schoufour, J. D., Oppewal, A., van Maurik, M. C., Hilgenkamp, T., Elbers, R. G., & Maes-Festen, D. (2022). Development and validation of a shortened and practical frailty index for people with intellectual disabilities. Journal of intellectual disability research : JIDR, 66(3), 240–249. https://doi.org/10.1111/jir.12907

Searle, S. D., Mitnitski, A., Gahbauer, E. A., Gill, T. M., & Rockwood, K. (2008). A standard procedure for creating a frailty index. BMC geriatrics, 8, 24. https://doi.org/10.1186/1471-2318-8-24

Streiner, D. L., & Norman, G. G. (2003). Health measurement scales: A practical guide to their development and use. Oxford University Press, 3, 172-193.

The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | The EQUATOR Network (equator-network.org)

Veronese, N., Stubbs, B., Noale, M., Solmi, M., Pilotto, A., Vaona, A., Demurtas, J., Mueller, C., Huntley, J., Crepaldi, G., & Maggi, S. (2017). Polypharmacy Is Associated With Higher Frailty Risk in Older People: An 8-Year Longitudinal Cohort Study. Journal of the American Medical Directors Association, 18(7), 624–628. https://doi.org/10.1016/j.jamda.2017.02.009

Wleklik, M., Uchmanowicz, I., Jankowska, E. A., Vitale, C., Lisiak, M., Drozd, M., Pobrotyn, P., Tkaczyszyn, M., & Lee, C. (2020). Multidimensional Approach to Frailty. Frontiers in psychology, 11, 564. https://doi.org/10.3389/fpsyg.2020.00564

Zwierzchowska, A., Celebańska, D., Rosołek, B., Gawlik, K., & Żebrowska, A. (2021). Is body mass index (BMI) or body adiposity index (BAI) a better indicator to estimate body fat and selected cardiometabolic risk factors in adults with intellectual disabilities?. BMC cardiovascular disorders, 21(1), 119. https://doi.org/10.1186/s12872-021-01931-9

Downloads

Published

22-07-2022

How to Cite

Celebańska, D., Gaweł, E., Kornatovská, Z., Rosołek, B., & Zwierzchowska, A. (2022). Prevalence of frailty syndrome and its predictors in the population of people with intellectual disability compared to the general population: a systematic review. Acta Salus Vitae, 10(1), 33–48. https://doi.org/10.58743/asv2022vol10no1.312