Common mechanisms in the pathogenesis of metabolic syndrome, atherosclerosis and breast carcinoma and the possibilities of using omega-3 polyunsaturated acids in their prevention and therapy
Keywords:
Polyunsaturated fatty acids, endotoxemia, microbiome, breast cancer, preventionAbstract
Breast cancer is the most common cancer disease among women in economically developed countries. The exact cause of the disease is not fully understood, but a variety of risk factors applies here. Consequently, the prevention has an important role in the reduction of incidence of breast carcinoma. Population of Central and Western Europe consume food with increased content of omega-6 polyunsaturated fatty acids at the expense of omega-3 polyunsaturated fatty acids. Consumption of high-fat diet rich in saturated fatty acids is associated with changes in the proportions of bacterial genera and species of intestinal microbiota. In this way there is development of dysbiosis. The mutual disproportions between the fatty acids, as well as dysbiosis, are risk factors, but also cause of the development of many chronic diseases, too.
References
Abbott SK, Else PL, Atkins TA, Hulbert AJ. (2012). Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance. Biochim Biophys Acta. 2012 May;1818(5):1309-17.
Agnoli C, Grioni S, Sieri S, Sacerdote C, Ricceri F, Tumino R, Frasca G, Pala V, Mattiello A, Chiodini P, Iacoviello L, De Curtis A, Panico S, Krogh V. (2015). Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort. PLoS One. 2015 Jun 1;10(6):e0128891.
Alokail MS, Al-Daghri NM, Al-Attas OS, Hussain T. (2009). Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women. Cardiovasc Diabetol. 2009 Jun 23;8:33.
Andel M, Polák J, Kraml P, Dlouhý P, Stich V. (2009). Chronic mild inflammation links obesity, metabolic syndrome, atherosclerosis and diabetes. Vnitr Lek. 2009 Jul-Aug;55(7-8):659-65.
Baker RG1, Hayden MS, Ghosh S. (2011). NF-κB, inflammation, and metabolic disease. NF-κB, inflammation, and metabolic disease. Cell Metab. 2011 Jan 5;13(1):11-22.
Bhandari R, Kelley GA, Hartley TA, Rockett IR. (2014). Metabolic syndrome is associated with increased breast cancer risk: a systematic review with meta-analysis. Int J Breast Cancer. 2014;2014:189384.
Bjørge T, Lukanova A, Jonsson H, Tretli S, Ulmer H, Manjer J, Stocks T, Selmer R, Nagel G, Almquist M, Concin H, Hallmans G, Häggström C, Stattin P, Engeland A. (2010). Metabolic syndrome and breast cancer in the me-can (metabolic syndrome and cancer) project. Cancer Epidemiol Biomarkers Prev. 2010 Jul;19(7):1737-45.
Boutagy NE, McMillan RP, Frisard MI, Hulver MW. (2016). Metabolic endotoxemia with obesity: Is it real and is it relevant? Biochimie. 2016 May;124:11-20.
Boyd NF, Stone J, Vogt KN, Connelly BS, Martin LJ, Minkin S. (2003). Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer. 2003 Nov 3;89(9):1672-85.
Calder PC. (2013). Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol. 2013 Mar;75(3):645-62.
Cani PD, Delzenne NM. (2009). Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curr Opin Pharmacol. 2009 Dec;9(6):737-43.
Cerf ME. (2013). Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013 Mar 27;4:37.
Cieślak M, Wojtczak A, Cieślak M. (2015). Role of pro-inflammatory cytokines of pancreatic islets and prospects of elaboration of new methods for the diabetes treatment. Acta Biochim Pol. 2015;62(1):15-21.
Cinkajzlová A, Mráz M, Haluzík M. (2017). Lymphocytes and macrophages in adipose tissue in obesity: markers or makers of subclinical inflammation? Protoplasma. 2017 May;254(3):1219-1232.
Cohen DH, LeRoith D. (2012). Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocr Relat Cancer. 2012 Sep 5;19(5):F27-45.
Deckelbaum RJ, Worgall TS, Seo T. (2006). n-3 Fatty acids and gene expression. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1520S-1525S.
Endogenous Hormones and Breast Cancer Collaborative Group, Key TJ, Appleby PN, Reeves GK, Roddam AW. (2010). Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol. 2010 Jun;11(6):530-42.
Erridge C, Attina T, Spickett CM, Webb DJ. (2007). A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr. 2007 Nov;86(5):1286-92.
Fabian CJ, Kimler BF, Hursting SD. (2015). Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015 May 4;17:62.
Fang Y, Sun M, Ramani K. (2015). Heat-passing framework for robust interpretation of data in networks. PLoS One. 2015 Feb 10;10(2):e0116121.
Ferguson JF, Mulvey CK, Patel PN, Shah RY, Doveikis J, Zhang W, Tabita-Martinez J, Terembula K, Eiden M, Koulman A, Griffin JL, Mehta NN, Shah R, Propert KJ, Song WL, Reilly MP. (2014). Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res. 2014 Mar;58(3):601-13.
Ferroni P, Riondino S, Buonomo O, Palmirotta R, Guadagni F, Roselli M. (2015). Type 2 Diabetes and Breast Cancer: The Interplay between Impaired Glucose Metabolism and Oxidant Stress. Oxid Med Cell Longev. 2015;2015:183928.
Galajda P. (2007). Metabolicky syndrom, kardiovaskularne a metabolicke rizika. In Via practica. 2007, vol. 4 (S4): 5 – 9.
Gonzalez-Quintela A, Alonso M, Campos J, Vizcaino L , Loidi L , Gude F. (2013). Determinants of serum concentrations of lipopolysaccharidebinding protein (LBP) in the adult population: the role of obesity. PLoS One. 2013;8(1):e54600.
Grisouard J, Dembinski K, Mayer D, Keller U, Müller B, Christ-Crain M. Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation. Diabetol Metab Syndr. 2011 Jul 20;3:16.
Haggag Mel-S, Elsanhoty RM, Ramadan MF. (2014). Impact of dietary oils and fats on lipid peroxidation in liver and blood of albino rats. Asian Pac J Trop Biomed. 2014 Jan;4(1):52-8.
Hauner D, Hauner H. (2014). Metabolic syndrome and breast cancer: is there a link? Breast Care (Basel). 2014 Apr;9(4):277-81.
Hawkesworth S, Moore SE, Fulford AJ, Barclay GR, Darboe AA, Mark H, Nyan OA, Prentice AM. (2013). Evidence for metabolic endotoxemia in obese and diabetic Gambian women. Nutr Diabetes. 2013 Aug 26;3:e83.
Huang PL. (2009). A comprehensive definition for metabolic syndrome. Dis Model Mech. 2009 May-Jun;2(5-6):231-7.
Huerta-Yépez S, Tirado-Rodriguez AB, Hankinson O. (2016). Role of diets rich in omega-3 and omega-6 in the development of cancer. Bol Med Hosp Infant Mex. 2016 Nov - Dec;73(6):446-456.
Chajès V, Sattler W, Stranzl A, Kostner GM. (1995). Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin-E. Breast Cancer Res Treat. 1995 Jun;34(3):199-212.
Chan DS, Norat T. (2015). Obesity and breast cancer: not only a risk factor of the disease. Curr Treat Options Oncol. 2015 May;16(5):22.
Imai Y, Dobrian AD, Weaver JR, Butcher MJ, Cole BK, Galkina EV, Morris MA, Taylor-Fishwick DA, Nadler JL. (2013). Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. Diabetes Obes Metab. 2013 Sep;15 Suppl 3:117-29.
Jung UJ, Choi MS. (2014). Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci. 2014 Apr 11;15(4):6184-223.
Kim KA, Gu W, Lee IA, Joh EH, Kim DH. (2012). High fat diet-induced gut microbiota inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One. 2012;7(10):e47713.
Kotepui M. (2016). Diet and risk of breast cancer. Contemp Oncol (Pozn). 2016;20(1):13-9.
Krajmalnik-Brown R, Ilhan ZE, Kang DW, DiBaise JK. (2012). Effects of gut microbes on nutrient absorption and energy regulation. Nutr Clin Pract. 2012 Apr;27(2):201-14.
Laugerette F, Furet JP, Debard C, Daira P, Loizon E, Géloën A, Soulage CO, Simonet C, Lefils-Lacourtablaise J, Bernoud-Hubac N, Bodennec J, Peretti N, Vidal H, Michalski MC. (2012). Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E374-86.
Laugerette F, Vors C, Géloën A, Chauvin MA, Soulage C, Lambert-Porcheron S, Peretti N, Alligier M, Burcelin R, Laville M, Vidal H, Michalski MC. (2011). Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem. 2011 Jan;22(1):53-9.
Laugerette F, Vors C, Peretti N, Michalski MC. (2011). Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation. Biochimie. 2011 Jan;93(1):39-45.
Ligibel J. (2011). Obesity and breast cancer. Oncology (Williston Park). 2011 Oct;25(11):994-1000.
Luo JB, Feng L, Jiang WD, Liu Y, Wu P, Jiang J, Kuang SY, Tang L, Tang WN, Zhang YA, Zhou XQ. (2017). Physical and Flavor Characteristics, Fatty Acid Profile, Antioxidant Status and Nrf2-Dependent Antioxidant Enzyme Gene Expression Changes in Young Grass Carp (Ctenopharyngodon idella) Fillets Fed Dietary Valine. PLoS One. 2017 Jan 24;12(1):e0169270.
Moreira AP, Texeira TF, Ferreira AB, Peluzio Mdo C, Alfenas Rde C. (2012). Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia. Br J Nutr. 2012 Sep;108(5):801-9.
Papa FR. (2012). Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Cold Spring Harb Perspect Med. 2012 Sep 1;2(9):a007666.
Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockene JK, Margolis KL, Limacher MC, Manson JE, Parker LM, Paskett E, Phillips L, Robbins J, Rossouw JE, Sarto GE, Shikany JM, Stefanick ML, Thomson CA, Van Horn L, Vitolins MZ, Wactawski-Wende J, Wallace RB, Wassertheil-Smoller S, Whitlock E, Yano K, Adams-Campbell L, Anderson GL, Assaf AR, Beresford SA, Black HR, Brunner RL, Brzyski RG, Ford L, Gass M, Hays J, Heber D, Heiss G, Hendrix SL, Hsia J, Hubbell FA, Jackson RD, Johnson KC, Kotchen JM, LaCroix AZ, Lane DS, Langer RD, Lasser NL, Henderson MM. (2006). Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006 Feb 8;295(6):629-42.
Pussinen PJ, Havulinna AS, Lehto M, Sundvall J, Salomaa V. (2011). Endotoxemia is associated with an increased risk of incident diabetes. Diabetes Care. 2011 Feb;34(2):392-7.
Radilla-Vázquez RB, Parra-Rojas I, Martínez-Hernández NE, Márquez-Sandoval YF, Illades-Aguiar B, Castro-Alarcón N. (2016). Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects. Obes Facts. 2016;9(1):1-11.
Ramos-Nino ME. (2013). The role of chronic inflammation in obesity-associated cancers. ISRN Oncol. 2013 May 30;2013:697521.
Rangel-Huerta OD, Aguilera CM, Mesa MD, Gil A. (2012). Omega-3 long-chain polyunsaturated fatty acids supplementation on inflammatory biomakers: a systematic review of randomised clinical trials. Br J Nutr. 2012 Jun;107 Suppl 2:S159-70.
Rivas-Urbina A, Benitez S, Perez A, Sanchez-Quesada JL. (2018). Modified low-density lipoproteins as biomarkers in diabetes and metabolic syndrome. Front Biosci (Landmark Ed). 2018 Jan 1;23:1220-1240.
Rose DP, Connolly JM. (1999). Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther. 1999 Sep;83(3):217-44.
Shankar E, Bhaskaran N, MacLennan GT, Liu G, Daneshgari F, Gupta S. (2015). Inflammatory Signaling Involved in High-Fat Diet Induced Prostate Diseases. J Urol Res. 2015 Jan 1;2(1). pii: 1018.
Shukla A, Grisouard J, Ehemann V, Hermani A, Enzmann H, Mayer D. (2009). Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines. Endocr Relat Cancer. 2009 Jun;16(2):429-41.
Stehle JR Jr, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP. (2012). Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1212-8.
Stoll BA. (2002). N-3 fatty acids and lipid peroxidation in breast cancer inhibition. Br J Nutr. 2002 Mar;87(3):193-8.
Sun S, Ji Y, Kersten S, Qi L. (2012). Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr. 2012 Aug 21;32:261-86.
Thiébaut AC, Chajès V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, Berrino F, Riboli E, Bénichou J, Clavel-Chapelon F. (2009). Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. Int J Cancer. 2009 Feb 15;124(4):924-31.
Tierney AC, McMonagle J, Shaw DI, Gulseth HL, Helal O, Saris WH, Paniagua JA, Gołąbek-Leszczyñska I, Defoort C, Williams CM, Karsltröm B, Vessby B, Dembinska-Kiec A, López-Miranda J, Blaak EE, Drevon CA, Gibney MJ, Lovegrove JA, Roche HM. (2011). Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome--LIPGENE: a European randomized dietary intervention study. Int J Obes (Lond). 2011 Jun;35(6):800-9.
Uzunlulu M, Telci Caklili O, Oguz A. (2016). Association between Metabolic Syndrome and Cancer. Ann Nutr Metab. 2016;68(3):173-9.
Vehovský K, Stupka R, Čítek R, Šprysl M, Okrouhlá M, Brzobohatý L. (2015). Factors affecting the fatty acid composition and fat oxidative stability in pigs. JCEA. 2015. 16(1): 122-129.
Viriyakosol S, Mathison JC, Tobias PS, Kirkland TN. (2000). Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide. J Biol Chem. 2000 Feb 4;275(5):3144-9.
Vona-Davis L, Howard-McNatt M, Rose DP. (2007). Adiposity, type 2 diabetes and the metabolic syndrome in breast cancer. Obes Rev. 2007 Sep;8(5):395-408.
Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS, Lau J. (2006). n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr. 2006 Jul;84(1):5-17.
Wang M, Cheng N, Zheng S, Wang D, Hu X, Ren X, Pei H, Ma H, Mu H, Bai Y. (2015). Metabolic syndrome and the risk of breast cancer among postmenopausal women in North-West China. Climacteric. 2015;18(6):852-8.
Wirfält E, Mattisson I, Gullberg B, Olsson H, Berglund G. (2005). Fat from different foods show diverging relations with breast cancer risk in postmenopausal women. Nutr Cancer. 2005;53(2):135-43.
Xin W, Wei W, Li X. (2012). Effects of fish oil supplementation on inflammatory markers in chronic heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2012 Sep 20;12:77.
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